Postdoctoral position
Biomedical Sciences, University of Birmingham
- Supervisors
Dr Maarten Hoogenkamp, Dr Vesna Stanulovic & Prof Geoffrey Brown
- Application deadline
To be posted with a deadline of 12th April 2024
- Funding status
Directly Funded Project (Students Worldwide)
- Project title
The selective action of RAR ligands
- Project description (max 500 words)
The cells that sustain a cancer and that are largely responsible for metastatic and aggressive disease are termed cancer stem cells. They are not eliminated by conventional treatments because chemotherapeutics and radiotherapy target dividing cells and cancer stem cells are quiescent. Cancer stem cells, therefore, provide a source of cells that replenish a cancer post-treatment leading to disease relapse. The many endeavours to find a means to eliminate cancer stem cells might provide a bona fide cure for some cancers. Activity of the retinoic acid receptor g (for the active metabolite of vitamin A) is important to cancer stem cell survival and proliferation. We have developed a synthetic compound that switches off the activity of this receptor. It kills cancer stem cells without affecting normal cells.
This project will study why the cancer stem cells die whereas normal cells are unaffected. This is important to developing the compound for use to treat patients. The project will use prostate cancer cell lines as model system and untransformed prostate epithelial cells as control. To investigate how retinoic acid receptor g regulates gene expression at DNA promoters and enhancers, we will perform genome wide sequencing techniques, such as RNA-seq, ChIP-seq and chromatin accessibility by DNase1-sequencing. The researcher will be trained in molecular biology techniques, including the genome wide techniques, and their analysis.
At the time of recruitment, the researcher must not have resided or carried out his/her main activity in the country of the beneficiary for more than 12 months in the 3 years immediately prior to recruitment under the project.
- Any funding information (max 100 words)
The person, of any nationality, will be recruited to work within the EU-funded Doctoral Network eRaDicate (https://www.eradicate-project.eu/) for 36 months. The UK isn’t an Associated Partner, and UKRI have agreed to underwrite (at an exchange rate of 1.180720) to give a fixed salary rate of £43,922.00 p. a., subject to review i.e. no increments or pay awards will be payable for the appointment duration. This salary rate will then be subject to UK Income Tax and Employee’s National Insurance contributions and Employee’s Superannuation and to UKRI reviewing the exchange rate every 12 months.
- Any references. BROWN G (2023). Targeting the retinoic acid pathway to eradicate cancer stem cells. International Journal of Molecular Sciences. 24, 2373.
- Categories. Cancer/Oncology, Clinical Science, Cancer Therapeutics, Development Biology
- Applications to m.hoogenkamp@bham.ac.uk; g.brown@bham.ac.uk
Postdoctoral Scientist in Neuroimmunology
We are looking for a motivated person with a PhD in a relevant field (e.g. immunology, neuroscience) or due to complete one within 6 months. You will join a friendly emerging lab developing an interdisciplinary collaborative research programme aimed at understanding how neurons modulate immune cells during antiviral and antitumour immunity.
You will be a creative scientist who is passionate about neuroimmunology, who will thrive in a laboratory with a supportive, friendly and inclusive atmosphere. A strong background working in vivo with peripheral neurons and/or developing organoids would be an advantage. Previous experience of immunology is not essential as long as the candidate is highly motivated to learn and brings other knowledge to the group.
This is a three year training and development position suitable for you if you have recently completed your doctoral studies, or you are looking to move into a new research discipline and/or need to further develop your research skills. Working with our world class scientists you will be working in an Institute renowned for its excellent scientific facilities and high-quality research.
For further information please contact Noe Rodriguez (noer@mrc-lmb.cam.ac.uk)
The MRC Laboratory of Molecular Biology (LMB) is a world-class research institute within UK Research and Innovation (UKRI). UKRI is an entity that brings together nine research and innovation partners, more information can be found at www.ukri.org and www.mrc-lmb.cam.ac.uk.
Postdoctoral position in Immunology
This is a 6-year funded postdoctoral position in the Immunology Group of the Department of Medicine and Life Sciences (MELIS), Universitat Pompeu Fabra https://www.upf.edu/web/genimmune
Research will focus mainly on studying how the immunometabolism of myeloid cells can shape adaptive immune responses and anti-tumor immunity. Focus on identifying transcription mechanisms that control inflammatory responses.
The position includes teaching activities in the subject of Immunology for students in the degrees of Medicine and Human Biology, with a maximum of 100 hours per academic year.
The candidate should have a solid academic background in Biomedicine or similar, a doctoral thesis oriented to immunology or inflammation, and ideally teaching experience in Immunology.
The following aspects will be valued for this position: experience working with mouse models of human disease, isolating and characterizing primary cells of the immune system, experience with RNA quantification by RT-qPCR, familiarity with multicolor and spectral flow cytometry and cell sorting, and experience with statistical analysis with GraphPad.
We will also value an advanced level of communication (written and spoken) in English, experience supervising master or PhD students, and previous involvement in preparing drafts for scientific
publications and grants.
Please send your applications to recruitment.melis@upf.edu, and to Cristina López Rodríguez: cristina.lopez-rodriguez@upf.edu. Include your curriculum, a motivation letter covering the aspects
that will be considered during the selection process (see above), and the contact (phone and email) of two principal investigators from whom references could be requested.
This call will be open till the 4th of May 2024.
Further information at https://www.upf.edu/web/biomed/job-offers Postdoctoral Position at Immunology Research group (Ref. MELIS-ACCES-2023-09)
Postdoctoral research fellow position
The current project focuses on immune consequences of genetic alterations affecting mitochondrial respiratory chain and metabolism. It will be developed in collaboration with the groups of Leif E. Sander (Charité, Berlin, Germany) and A.-Emmanuel Saliba (Helmhotlz, Würzburg, Germany).
The successful candidate will be in charge of leading the development of a new approach for single-cell sequencing, and the implementation of molecular tools to edit the mitochondrial genome to assess functional immune outcomes of mitochondrial diseases.
The candidate is expected to:
1. Design experiments and formalize experimental protocols.
2. Conduct wet bench experiments with primary human immune cells and patient samples.
3. Analyze experimental data and keep organized data archives.
4. Interact and collaborate productively with bioinformatic staff and other research partners.
5. Present data in lab meetings and communicate research outputs in scientific meetings.
6. Participate actively to the production of manuscripts for publication.
Candidate profile: Applicants must hold a PhD in biological sciences (preferably in immunology or genetic), and should have a strong interest in metabolism and infection biology.
Fluency in English (spoken and written) is required. French is a bonus, but not required.
Successful candidates will have a strong background in immunology, cellular biology or molecular biology. Background in single cell sequencing approaches will be well considered.
Further scientific skills should include standard techniques like cell culture, qPCR, immunoblotting, basic molecular biology, or mouse handling. Most importantly, candidates should be curious and ambitious. Applicants should demonstrate good communication skills, autonomy and a passion for scientific thinking and experimental work.
Candidates should send a letter containing a statement of interest, curriculum vitae, and the names of two mentors for reference to johan.garaude@inserm.fr
The selection process will include an oral presentation and interview.
Salary will be in accordance with the university of Bordeaux scale, depending on experience.
We offer a renewable one-year contract funded by the French ANR.
The Minutti lab is recruiting!
We are looking for an enthusiastic postdoc to join our team.
Our goal is to identify the mechanisms by which the lungs communicate with the bone marrow in settings of emergency to modulate hematopoiesis – focusing on dendritic cell output.
More about the project:
In the lab we hypothesise that different subsets of cDC2s are required to activate TH1 vs TH2 T helper functions and that each subset of the cDC2 family derives from a progenitor that has been functionally specified in the bone marrow, the tissue that generates virtually all the cells of the immune system. Given the relatively short lifespan of a cDC in tissues, we propose that cDC2s and their precursors do not have enough time to be fully “instructed” by their niche but rather require to be pre-specified in the bone marrow to meet the needs of these cells at the periphery. We envisage that, during an immune response, there is a distal communication between the site of infection and the bone marrow that allows the latter tissue to modulate the output of peripheral cDC2s and satisfy the cDC functional requirements at the site of infection or inflammation. We anticipate that the lung – bone marrow communication is mediated by the circulation, or intriguingly by the nervous system. This communication axis could ensure successful immune responses against certain pathogens but might be highjacked by the tumour during cancer disease. Based on this hypothesis we want to know what is the cellular and molecular identity of the key players mediating the lung – bone marrow communication axis.
Job add and The Minutti lab website: https://euraxess.ec.europa.eu/jobs/181169 https://fchampalimaud.org/research/groups/minutti
If you are interested apply in the portal or, send your CV, motivation letter and 2-3 reference letter to:
carlos.minutti@research.fchampalimaud.org
Postdoctoral fellow position
Within the Enamorado Lab, a focal point of investigation lies on understanding the neuroimmune regulation of injury and repair at the barrier tissues, in the context of the microbiota. Dr. Enamorado’s research aims to unravel the 1) Peripheral Neuroimmune Regulation of Injury and Repair at Barrier Tissues. 2) Brain Sensing of Tissue Injury and Repair. 3) Impact of Tissue Injury and Repair on Mental Health and vice versa. By advancing our understanding of the neuroimmune mechanisms at play, we will contribute to the development of personalized, targeted therapies that can make a meaningful difference in patients live.
PhD in biological sciences (Immunology, Neuroscience, or related fields)
Candidates will be evaluated based on their merits. High energy, enthusiasm, and the ability to bridge new concepts and fields are desired.
More information about our laboratory: https://labs.icahn.mssm.edu/enamoradolab/
Prospective applicants are encouraged to send their application, comprising a cover letter detailing their scientific interests and alignment with our mission, along with a CV or Biosketch and contact information for three references, to nerismichel.enamoradoescalona@mssm.edu .
Postdoctoral position
The Mechanoadaptation and Caveolae Biology Lab at CNIC, led by Miguel Ángel del Pozo is recruiting a postdoctoral fellow to study the principles by which mechanical forces, tissue remodeling, inflammation and aging drive cardiovascular disease. The selected candidate will combine state-of-the-art immunobiology and exosome biology, advanced omics and biophysics, with mouse disease models, in collaboration with top laboratories in the field (David Sancho, CNIC-Madrid, Jacob Bentzon, Aarhus U.; Martin Schwartz, Yale U.), to explore how cells respond to mechanical cues stemming from their environment (blood flow, muscle contraction, stiffening associated with aging…) and how this drives tissue remodeling and immunomodulation.
We encourage highly motivated candidates to apply to the upcoming Juan de la Cierva programme call. Eligible candidates should possess a strong academic record, with first authorship of at least one Q1 publication. Previous experience in either extracellular matrix biology, immunity and the biology of inflammation, proteomics, metabolism, animal models, and/or cardiovascular disease will be very positively valued. A letter of motivation, CV and contact details of 3 references should be addressed to anaisabel.martinez@cnic.es & madelpozo@cnic.es stating “JdC Candidate” in the subject. Informal inquiries for further information can be requested at +34 914531200, ext. 70488.