Two fully funded postdoctoral position is available in the laboratory of Jorge Moscat (https://www.moscatdiazmecolab.org) to study fundamental aspects of cell transdifferentiation and metaplasia in the crosstalk between the stroma and cancer cells in the tumor microenvironment, with special attention to colorectal cancer. The laboratory combines molecular and cellular studies in organoids and mouse models and the interrogation of human gene expression datasets bioinformatically and tissue microarrays from human cancer specimens by multiplex immunofluorescence imaging. The project is based on our recent publications on this topic: Nakanishi et al., 2018 Immunity; Reina-Campos et al., 2019 Cancer Cell; Kudo et al., 2020 Cancer Cell; Kasashima et al., 2021 Developmental Cell; Linares et al., 2021 Molecular Cell; Martinez-Ordoñez et al., 2023 Cancer Cell. Candidates with a Ph.D. or M.D. degree should have lab experience in molecular and cellular biology techniques and expertise in mouse models. Interested applicants should submit a single PDF file containing the CV and contact information (e-mail address and phone number) of three references to jom4010@med.cornell.edu.

 

One fully funded postdoctoral position is available in the laboratory of Maria Diaz-Meco (https://www.moscatdiazmecolab.org) to study the crosstalk between metabolism and epigenetic control in the tumor microenvironment of therapy-resistant prostate cancer with a special emphasis on the process of lineage plasticity and the role of cancer-associated fibroblasts in promoting epithelial cancer cell mesenchymal differentiation. The project is based on our recent publications on this topic: Linares et al., 2017 Cell Metab; Huang et al., 2019 Cancer Cell; Reina-Campos et al., 2019 Cancer Cell; Linares et al., 2023 Cell Rep.The laboratory has developed unique mouse models and cell organoid systems to interrogate these mechanisms in physiologically relevant contexts. Those studies are combined with extensive use of bioinformatics interrogation of human gene expression datasets and the use of state-of-the-art spatial imaging of human cancer specimens. Candidates should have a Ph.D. or M.D., be highly motivated, and with experience in molecular and cellular techniques and basic bioinformatics tools. Interested applicants should submit a single PDF file containing the CV and contact information (e-mail address and phone number) of three references to mtd4001@med.cornell.edu.

 

Spread the love