The current project focuses on immune consequences of genetic alterations affecting mitochondrial respiratory chain and metabolism. It will be developed in collaboration with the groups of Leif E. Sander (Charité, Berlin, Germany) and A.-Emmanuel Saliba (Helmhotlz, Würzburg, Germany).

The successful candidate will be in charge of leading the development of a new approach for single-cell sequencing, and the implementation of molecular tools to edit the mitochondrial genome to assess functional immune outcomes of mitochondrial diseases.
The candidate is expected to:
1. Design experiments and formalize experimental protocols.
2. Conduct wet bench experiments with primary human immune cells and patient samples.
3. Analyze experimental data and keep organized data archives.
4. Interact and collaborate productively with bioinformatic staff and other research partners.
5. Present data in lab meetings and communicate research outputs in scientific meetings.
6. Participate actively to the production of manuscripts for publication.

Candidate profile: Applicants must hold a PhD in biological sciences (preferably in immunology or genetic), and should have a strong interest in metabolism and infection biology.
Fluency in English (spoken and written) is required. French is a bonus, but not required.
Successful candidates will have a strong background in immunology, cellular biology or molecular biology. Background in single cell sequencing approaches will be well considered.
Further scientific skills should include standard techniques like cell culture, qPCR, immunoblotting, basic molecular biology, or mouse handling. Most importantly, candidates should be curious and ambitious. Applicants should demonstrate good communication skills, autonomy and a passion for scientific thinking and experimental work.

Candidates should send a letter containing a statement of interest, curriculum vitae, and the names of two mentors for reference to johan.garaude@inserm.fr
The selection process will include an oral presentation and interview.
Salary will be in accordance with the university of Bordeaux scale, depending on experience.
We offer a renewable one-year contract funded by the French ANR.